Document Type : Original Research
Authors
1
Internal medicine department ,AFCM, Cairo, Egypt
2
Hematology department , Armed Forces college of Medicine (AFCM), Cairo, Egypt
3
Hematology department, Armed Forces College of Medicine (AFCM),Cairo, Egypt
4
Radiology department ,Military Medical Academy , Cairo, Egypt
5
Hematology department, Military Medical Academy, Cairo, Egypt
6
Hematology department, Military Medical Academy , Cairo, Egypt
7
Internal medicine, faculty of medicine Cairo University, Cairo, Egypt Hematology department, AFCM, Cairo, Egypt
Abstract
Background
It has been discovered that patients with myeloproliferative neoplasms (MPNs) have an increased risk of thrombosis in presence of JAk2V617F mutation that causes a thrombophilic phenotype.
Ejection fraction (EF) and lipid profile assessment are accepted as markers of subclinical atherosclerosis and can help the clinician to reclassify the cardiovascular risk of patients into a lower or higher risk category.
Objective
The aim of the study was to identify whether the risk of arterial atherosclerosis increases in MPNs patients below 60 years in comparison to normal population regardless the known risk factor of atherosclerosis as diabetes, Hypertension and smoking.
Methods
The study included 48 patients of MPNs and 48 control samples were selected from the same places .the control were chosen as one by one to match the case in age, sex, smoking, HTN and DM. All the patients were subjected to: history taking and physical examination. Laboratory investigations include CBC and lipid profile. Radiological investigations in form of Trans thoracic Echo for EF assessment.
Results
The MPNs patients Showed statistically significant difference (P value 0.035) in the EF assessment when compared to controls and significant increase in lipid profile (LDL, HDL, TGs) despite similar risk in DM and HTN, With no significant difference between PV and ET cases regarding measurement of EF and lipid profile assessment (p value 0.352). This may point to the main drive for impaired EF and lipid profile is related mainly to JAK2 gene mutation.
Conclusion
JAK2 gene mutation is a risk factor for atherosclerosis.
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