Background: Since the first reports of COVID-19 disease, it has become clear that acute respiratory distress syndrome was responsible for a significant number of deaths among infected patients. Several studies have linked increased levels of proinflammatory cytokines in serum to pulmonary inflammation and extensive lung damage.Among proinflammatory cytokines, Interleukin-6 is the key cytokine that contributes to an inflammatory storm. Several studies have found that elevated IL-6 levels are associated with the severity of COVID-19 symptoms and death.Tocilizumab is monoclonal antibody that antagonizes the effect of IL-6. Early cytokine storm treatment may have benefits on COVID-19 patients’ survival.
Methods:The present study was conducted on 91 COVID-19 patients, admitted to intensive care unit and took tocilizumab.The IL-6 serum level data were collected from patients’ files pre and post-tocilizumab administration. Regarding these data, we could determine the clinical outcome after treatment.
Results:We demonstrated that there was a decrease in IL-6 serum level within both mild and moderate severity grades by 16.3% and 38.4% respectively, while there was a significant increase in the patients who had severe grade by 162%. There was a significant decrease in IL-6 serum level within recovered group by 66.1% and a significant increase within the mortality group by 256% pre and post-injection with tocilizumab.
Conclusion: IL-6 serum level may be a major indicator but not the sole driver in the pathology of COVID-19. So, when we assess IL-6 serum level, we should take into consideration other cytokines, and the usage of combinations of many blockages for these cytokines may improve the outcome.
Hussien, M., Fathi, M., Mahmoud, F., Abdelrahman, R., El-Gohary, M., & Taha, A. (2023). Efficacy Of Tocilizumab On Critical Intensive Care Unit COVID-19 Patients: Retrospective Study Among Egyptian Armed Forces Hospitals.. ARCADEs of MEDICINE, 1(1), 65-73. doi: 10.21608/arcmed.2023.220645.1036
MLA
Mahmoud Khaled Hussien; Marwa Saad Fathi; Fatma Mostafa Mahmoud; Raafat Zaher Abdelrahman; Mohamed Abd El-Salam El-Gohary; Ahmed Gad Taha. "Efficacy Of Tocilizumab On Critical Intensive Care Unit COVID-19 Patients: Retrospective Study Among Egyptian Armed Forces Hospitals.". ARCADEs of MEDICINE, 1, 1, 2023, 65-73. doi: 10.21608/arcmed.2023.220645.1036
HARVARD
Hussien, M., Fathi, M., Mahmoud, F., Abdelrahman, R., El-Gohary, M., Taha, A. (2023). 'Efficacy Of Tocilizumab On Critical Intensive Care Unit COVID-19 Patients: Retrospective Study Among Egyptian Armed Forces Hospitals.', ARCADEs of MEDICINE, 1(1), pp. 65-73. doi: 10.21608/arcmed.2023.220645.1036
VANCOUVER
Hussien, M., Fathi, M., Mahmoud, F., Abdelrahman, R., El-Gohary, M., Taha, A. Efficacy Of Tocilizumab On Critical Intensive Care Unit COVID-19 Patients: Retrospective Study Among Egyptian Armed Forces Hospitals.. ARCADEs of MEDICINE, 2023; 1(1): 65-73. doi: 10.21608/arcmed.2023.220645.1036
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